Highly active antiretroviral therapy (HAART) is a therapeutic intervention developed by clinicians and researchers in order to fight the HIV pandemic. It has contributed to a significant reduction in AIDS-related mortality and allowed many previously bed-ridden patients to live healthier, more productive lives. Until the advent of HAART in 1996, a diagnosis of HIV infection was considered a death sentence. A decade later, the disease has been transformed into a serious, yet potentially manageable, medical condition for thousands of people living with HIV/AIDS in the developed world - almost overnight creating a generation of "HIV Survivors" - and forged a global movement to ensure that its Lazarus-like benefit reaches millions more in the developing world. This book reviews the achievements of HAART over the past decade, and explores the challenges that may arise in the future. It recounts key landmarks in the development and introduction of HAART from the perspective of clinicians, researchers, economists, sociologists, and public policy experts, including the co-discoverers of HIV, Luc Montagnier and Robert Gallo.

Foreword, Luc Montagnier & Robert Gallo 1. Introduction, Jose M Zuniga, Alan Whiteside, Amin Ghaziani & John G Bartlett A Decade of HAART: Trials, Tribulations, and Successes 2. A world ravaged by a disease without HAART, Jose M Zuniga & Amin Ghaziani 3. Turning the world on its ear: defining milestones on the road to HAART, Michel D Kazatchkine & Lieve Fransen 4. Outcome and impact of 10 years of HAART, Eduard J Beck & Rochelle P Walensky 5. Highly Active Anti-Retroviral Therapy in HIV-infected children: a decade later, Arry Dieudonne, James A McIntyre, Federica Freginese, Carla Giaqutinto & James M Oleske HAART in High Human Development Countries 6. Country review: Australia, Kathleen Glenday, Kathy Petoumenos, Matthew G Law & David A Cooper 7. Country review: Chile, Marcelo J Wolff 8. Country review: Germany, Eva Wolf & Hans Jaeger 9. Country review: Italy, Renato Maserati 10. Country review: United States of America, Renslow Sherer 11. The HIV Outpatient Study (HOPS) and the Multicenter AIDS Cohort Study, Frank J Palella Jr, Anne C Moorman, John T Brooks; John Phair, Lisa Jacobson, Roger Detels, Joseph Margolick & Charles Rinaldo 12. The French Hospital Database on HIV (FHDH) ANRS CO.4, Dominique Costagliola 13. EuroSIDA: A prospective observational study of chronic HIV infection 13-1 Across the European continent, Jens D Lundgren, Ole Kirk & Amanda Mocroft 14. The Swiss HIV Cohort (SHCS), Huldrych F Gunthard & Bernard Hirschel 15. The OPTIMA Cohort, Mark Holodniy HAART in Medium Human Development Countries 16. Country review: Brazil, Celso Ferreira Ramos-Filho & Cledy Eliana dos Santos 17. Country review: China, Zhang Fu-Jie, Ray Y Chen, Selina N Lo and Ma Ye 18. Country review: South Africa, Robin Wood & Des Martin 19. Country review: Thailand, Praphan Phanuphak, Sanchai Chasombat & Jintanat Ananworanich 20. Cohort studies in Brazil: Projet Praca Onze, Mauro Schechter & Suely Hiromi Tuboi 21. The HIV Netherlands-Australia-Thailand research collaboration (HIVNAT), Kiat Ruxrungtham HAART in Low Human Development Countries 22. Country review: Haiti, Serena Koenig, Julia Carney, Peter Bendix & Jean William Pape 23. Country review: Malawi, Erik J Schouten, Simon D Makombe, Anthony D Harries & Kelita Kamoto 24. Country review: Senegal, Papa Salif Sow 25. Country review: Zambia, Moses Sinkala & Benjamin H Chi Future Challenges in the Next Decade of HAART 26. Clinical challenges of lifetime HAART, Roger Paredes, Renslow Sherer & Bonaventura Clotet 27. Maintaining and developing health systems to sustain HAART, Stephanie Nixon & Nina Veenstra 28. Redefining HIV/AIDS care delivery in the face of human resource scarcity, Mario Roberto Dal Poz, Norbert Dreesch & Dingie van Rensburg 29. Conclusion: closing the gap - one world, one standard, Peter Piot, Julian Fleet & Siddharth Dube