Until now, those in need of information on infectious diseases had to choose between encyclopedic reference texts or the infectious diseases sections in standard textbooks in internal medicine. Now there is a better alternative-Clinical Infectious Diseases fills the long-standing need for a practical yet comprehensive work that offers easy, convenient access to the topic. Of interest to internists, infectious disease specialists, and residents in training, the book is structured to give the reader essential information about the etiology and pathogenesis of various infectious diseases, and focuses on the clinical issues of managing, diagnosing, and treating patients with all types of infection. The editors and contributors are internationally known and recognized experts, and aim to validate the increasingly universal approaches to the diagnosis and treatment of infections worldwide. Emphasizing the clinical presentation of the patient by organ-system, diagnostic considerations including geographic, anatomic and microbiologic concerns, are addressed in detail. Diagnostic algorithms are provided, and specific choices of antimicrobial therapy are discussed and compiled in a user-friendly tabular format. Preventive measures for different types of infections are also addressed. Sections devoted to infections in special patient/risk groups, such as the post operative patient, the patient with immunodeficiency, the trauma patient, and the burn patient are included, as well as coverage of infections of travelers to tropical countries, and patients who have been bitten or scratched by animals or insects. A detailed presentation on HIV infection includes discussions of epidemiology, pathogenesis, immunology, clinical manifestations and antiviral treatment, as well as management of opportunistic infections.

1. Historical Notes, Harold P. Lambert 2. Infectious Diseases: An Overview, Richard K. Root I. Pathophysiology Of Infectious Diseases 3. Pathophysiology of Bacteria and Bacterial Diseases, David A. Relman 4. Pathophysiology of Viruses and Viral Diseases, David M. Koelle and Lawrence Corey 5. Introduction to Parasitic Protozoa and Helminths, Adel A.F. Mahmoud 6. Introduction to Fungi and Fungal Diseases, John E. Edwards, Jr. and Peter G. Pappas 7. Epidemiology of Clinical Infectious Diseases, Richard A. Goodman and James M. Hughes 8. Epidemiology and Control of Infectious Diseases in Health Care Facilities, Huan J. Chang and William Jarvis 9. Host Responses to Infection: Fever, Hyperthermia and Hypothermia, Richard K. Root 10. The Acute Inflammatory Response, Jan Verhoef 11. The Specific Immune Response, John M. Dwyer Response II. Diagnostic Methods In Infectious Disease 12. Modern Imaging Techniques in Infectious Disease, Eric J. Stern, Hanh V. Nghiem, John F. Hiehle, Jr., and David H. Lewis 13. Hematologic Alterations in Infectious Disease Patients, Photis Beris and Francis A. Waldvogel 14. Metabolic and Endocrine Alterations in Infectious Disease Patients, Francis A. Waldvogel 15. Specimen Management and Rapid Detection of Infectious Agents, Fred C. Tenover 16. Clinical Bacteriology, James J. Plorde 17. Clinical Virology, Rhoda Ashley and Larry Corey 18. Clinical Mycology, Micheal A. Pfaller 19. Clinical Parasitology, James J. Plorde 20. Rickettsia and Chlamydia, W. Conrad Liles and Walter E. Stamm III. Anti-Microbial Drugs: Principles and Usage 21. Mechanisms of Antimicrobial Action and Resistance, George A. Jacoby 22. Pharmacology of Antimicrobials, Sandra L. Preston and George L. Drusano 23. Antimicrobial Toxicities and Drug Interaction, James E. Leggett and S.R. Raber 24. Selection of Antimicrobials for Treatment, Jay P. Sanford 25. Outpatient Parenteral Therapy of Serious Infections, Alan D. Tice 26. Control of Antimicrobial Usage, Peter Davey 27. Penicillins, Catherine M.Creticos and John N. Sheagren 28. Cephalosporins, James B. Malow and John N. Sheagren 29. Other Beta-Lactam Antibiotics: Penems and Carpapenems, Monobactams, Pierre Tattevin, Guillaume Breton, and Claude Carbon 30. Aminoglycosides, David N. Gilbert 31. Glycopeptides, Adel Sulaiman, Robert M. Rakita, and Barbara E. Murray 32 Macrolides and Clindamycin, Howard S. Gold and Robert C. Moellering, Jr. 33. Tertracyclines and Chloramphenicol, Thomas M. Hooton 34. Fluoroquinolones, Ralf Stahlmann and Hartmut Lode 35. Sulfonamides and Trimethoprim, Stephen E. Sanche and Allan R. Ronald 36. Miscellaneous Antibacterial Drugs, Gordon Dow and Allan Ronald 37. Antimycobacterial Drugs, Charles A. Peloquin and Michael D. Iseman 38. Antimicrobial Therapy for Bacterial Diseases, David H. Spach and W. Conrad Liles 39. Antiviral Drugs and Therapy, Catherine Diamond and Lawrence Corey 40. Antiparasitic Drugs and Therapy, Keith Armitage 41. Antifungal Drugs, Peter G. Pappas and John Edwards 42. Selection of Antifungal Drugs for Deep Mycoses, Peter G. Pappas and John Edwards IV. Vaccines And Immunomodulatory Agents 43. Principles of Vaccine Development and Immunoprophylaxis, Gordon Ada 44. Passive Immunoprophylaxis and Treatment, James E. Pennington 45. Specific Vaccines, Paul T. Heath and E. Richard Moxon 46. Growth Factors, Immunomodulators and Cytokines, Brigitta U. Mueller and Philip A. Pizzo V. Infectious Disease Syndromes 47. Approach to the Patient with Fever: Acute Febrile Illness, Ethan Rubinstein and David Hassin 48. Fever in Hospitalized Patients, David N. Schwartz and Robert A. Weinstein 49. Fever of Unknown Origin, Richard K. Root and Robert G. Petersdorf 50. Bacteremia, Sepsis, and Septic Shock, Giorgio Zanetti, Jean-Daniel Baumgartner, and Michel-Pierre Glauser 51. Infections with Rash, Mort Swartz 52. Cellulitis and Abscesses, Dennis L. Stevens 53. Infectious Diseases with Lymphadenopathy or Lymphadenitis, Ivor Byren 54. Upper Respiratory Tract Infections, Charles B. Smith 55. Bronchitis and Bronchiectasis, C.M. Tang and C.P. Conlon 56. Acute Pneumonia, Feng Yee Chang and Victor L. Yu 57. Cavitary Pulmonary Disease, John L. Johnson and Jerrold J. Ellner 58. Diffuse Pulmonary Infiltrates and Acute Respiratory Distress Syndrome (ARDS), Kenneth P. Steinberg 59. Pleurisy and Empyema, H. Lode, T. Schaberg, J. Eller 60. Intraoral Infections, John S. Greenspan and Deborah Greenspan 61. Diarrhea and Gastroenteritis, Herbert L. DuPont and H. Irving Schweppe 62. Hepatitis, Margaret C. Shuhart and Robert L. Carithers, Jr. 63. Pyogenic Biliary Tract and Hepatic Infections, Jan V. Hirschmann 64. Infectious Complications of Pancreatitis, E. Patchen Dellinger 65. Peritonitis and Intra-abdominal Abscesses, E. Patchen Dellinger 66. Infective Endocarditis, Adolf W. Karchmer 67. Intravenous Catheter-related Infections, Suppurative Thrombophlebitis and Mycotic, Aneurysms: Diagnosis, Risk Factors, and Management 68. Myocarditis, Pericarditis, A. Martin Lerner 69. Acute and Chronic Urinary Tract Infections, Walter E. Stamm 70. Genital Herpes and Genital Ulcer Disease, H. Hunter Handsfield 71. Urethritis, Epididyimitis, Orchitis, Prostatitis, Kimberley K. Fox, Susan F. Isbey, Myron S. Cohen, and Culley C. Carson, III 72. Vulvovaginitis, Cervicitis, and Pelvic Inflammatory Disease (PID), Joanne Embree and R. Brunham 73. Meningitis, Young S. Kim and Martin G. Tauber 74. Encephalitis, R. Tyler Frizzell and Richard J. Whitley 75. Infections Associated with Myelopathy, Radiculopathy, and Neuropathy, Christina M. Marra 76. Focal Central Nervous System Infections, Allan R. Tunkel and W. Michael Scheld 77. Ocular and Periocular Infections, Annabelle A. Okada and Ann Sullivan Baker 78. Osteomyelitis, Jon T. Mader, Mauro Ortiz, and Jason H. Calhoun 79. Infectious and Post-Infectious Arthritis, Mekennon Abebe, Lee D. Kaufman, and Benjamin J. Luft 80. Myositis and Fasciitis, Dennis L. Stevens 81. Chronic Fatigue Syndrome, Dedra Buchwald VI. Infections In Special Patient/Risk Groups 82. Post-Surgical Wound Infections, Ronald Lee Nichols 83. Burn Infections, Roberta Mann, Baiba J. Grube, David M. Heimbach 84. Infections Complicating Traumatic Injury, Wayne N. Campbell 85. Prosthetic Device Infections, Werner Zimmerli 86. Infection in the Immunodeficient Patient, M. Aoun and J. Klastersky 87. Infection in the Organ Transplant Recipient, Robert H. Rubin and Nina E. Tolkoff-Rubin 88. Hematopoietic Stem Cell Transplantation, Raleigh A. Bowden 89. Infection in the Malnourished Patient, Phillipe LePage, Achim Schwenk, Patrick De Mol, and Jean-Paul Butzler 90. Intravenous Drug Abuse and Infection, Christian Ruef 91. Alcohol Abuse, Host Defenses and Infection, Rob Roy MacGregor 92. Fever in Travelers to Tropical Countries, W. Conrad Liles and Wesley C. Van Voorhis 93. Diarrhea in Travelers to Tropical Countries, Herbert L. DuPont and H. Irving Schweppe 94. Eosinophilia in Travelers to Tropical Countries, Adel A.F. Mahmoud 95. Infections after Animal Bites and Scratches, Stephen J. Gluckman 96. Ectoparasite-Related Infections, David H. Spach and Karen M. Van de Velde VII. HIV Infection and AIDS 97. Epidemiology and Prevention, Francoise Crabbe, Marie Laga and Peter Piot 98. Pathogenesis: Molecular Biology and Virology of HIV, J. Michael Kilby and George M. Shaw 99. Immunology, Sharon A. Stranford and Jay A. Levy 100. Clinical Manifestations of HIV Infections and AIDS, Ann C. Collier, Christina M. Marra, and Lili A. Sacks 101. Antiretroviral Therapy, Lawrence Corey 102. Therapy of Opportunistic Infections, Jason I.N. Tokumoto and Harry Hollander 103. Vaccines, Dani P. Bolognesi

"The real strength of this text is its patient-oriented focus. ...Chapters are concise and relevant to problems that clinicians see. ...An admirable job is done of covering HIV infection and AIDS. ...Students, house staff, and clinicians will find this text very informative and enjoyable." --Clinical Infectious Diseases