The revolution in psychiatry that began in earnest in the 1960s led to dramatic advances in the understanding and treatment of manic-depressive illness. Hailed as the most outstanding book in the biomedical sciences when it was originally published in 1990, Manic-Depressive Illness was the first to survey this massive body of evidence comprehensively and to assess its meaning for both clinician and scientist. It also vividly portrayed the experience of manic-depressive illness from the perspective of patients, their doctors, and researchers. Encompassing an understanding about the illness as Kraeplin conceived of it- about its cyclical course and about the essential unity of its bipolar and recurrent unipolar forms- the book has become the definitive work on the topic, revered by both specialists and nonspecialists alike. Now, in this magnificent second edition, Drs. Frederick Goodwin and Kay Redfield Jamison bring their unique contribution to mental health science into the 21st century. In collaboration with a team of other leading scientists, a collaboration designed to preserve the unified voice of the two authors, they exhaustively review the biological and genetic literature that has dominated the field in recent years and incorporate cutting-edge research conducted since publication of the first edition. They also update their surveys of psychological and epidemiological evidence, as well as that pertaining to diagnostic issues, course, and outcome, and they offer practical guidelines for differential diagnosis and clinical management. The medical treatment of manic and depressive episodes is described, strategies for preventing future episodes are given in detail, and psychotherapeutic issues common in this illness are considered. Special emphasis is given to fostering compliance with medication regimens and treating patients who abuse drugs and alcohol or who pose a risk of suicide. This book, unique in the way that it retains the distinct perspective of its authors while assuring the maximum in-depth coverage of a vastly expanded base of scientific knowledge, will be a valuable and necessary addition to the libraries of psychiatrists and other physicians, psychologists, clinical social workers, neuroscientists, pharmacologists, and the patients and families who live with manic-depressive illness.

PART II: Clinical Studies. ; 4. Course and Outcome; 5. Epidemiologoy; 6. Childhood and Adolescence; 7. Comorbidity; 8. Suicide; PART III: Psychological Studies. ; 9. Neuropsychology; 10. Personality; 11. Assessment; 12. Creativity; PART IV: Pathophysiology. ; 13. Genetics; 14. Neurobiology; 15. Neuroanatomy and Neuroimaging; 16. Sleep and Circadian Rhythms; PART V: Treatment. ; 17. Fundamentals of Treatment; 18. Medical Treatment of Hypomania, Mania, and Mixed States; 19. Medical Treatment of Depression; 20. Maintenance Medical Treatment; 21. Medication Adherence; 22. Psychotherapy; 23. Treatment of Children and Adolescents; 24. Treatment of Comorbidity; 25. Clinical Management of Suicide Risk; Appendix: Resources for Information about Bipolar Disorder and Related Topics. ; References. ; Index.

Frederick K. GoodwinDirector, Center on Neuroscience, Behavior and Society, George Washington University Medical Center, Kay Redfield JamisonProfessor of Psychiatry, Johns Hopkins University School of Medicine

"...Goodwin and Jamison have harvested the intellectual growth which the earlier volume has spawned and published an extraordinary second edition. Here the authors capture once again the whole range of the current views of these disorders in a way that points to the future, not only for those who treat people with these recurrent illnesses but for all interested in understanding the enormous scientific growth that the psychobiology of affect has experienced in the last decade and a half. This book has no peer. It again has set the standard by which all textbooks in psychiatry will be judged."--Eric R. Kandel, MD, University Professor of Physiology and Cell Biophysics, Psychiatry, Biochemistry and Molecular Biophysics at Columbia University and winner of the 2000 Nobel Prize for Medicine