This is a new edition of the popular textbook, which describes the design and analysis of medical research studies, using many real examples. It includes many questions for readers to test their knowledge. • Clear, understandable, correct account of the statistical principles used in the medical literature • Companion volume of statistical questions for evidence-based medicine • Contains many examples drawn from medical research • Contains many exercises, including 100 multiple choice questions • Undergraduate and postgraduate material clearly indicated   Contents: 1. Introduction 2. The design of experiments 3. Sampling and observational studies 4. Summarizing data 5. Presenting data 6. Probability 7. The normal distribution 8. Estimation 9. Significance tests 10. Comparing the means of small samples 11. Regression and correlation 12. Methods based on rank order 13. The analysis of cross-tabulations 14. Choosing the statistical method 15. Clinical measurement 16. Mortality statistics and population structure 17. Multifactorial methods 18. Determination of sample size 19. Solutions to exercises References Index

1. Introduction 2. The design of experiments 3. Sampling and observational studies 4. Summarizing data 5. Presenting data 6. Probability 7. The normal distribution 8. Estimation 9. Significance tests 10. Comparing the means of small samples 11. Regression and correlation 12. Methods based on rank order 13. The analysis of cross-tabulations 14. Choosing the statistical method 15. Clinical measurement 16. Mortality statistics and population structure 17. Multifactorial methods 18. Determination of sample size 19. Solutions to exercises References Index

J. Martin Bland , Professor of Health Statistics, Department of Health Sciences, University of York, UK